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Cancer
Sulli G, Manoogian ENC, Taub PR, Panda S. Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases. Trends in Pharmacological Sciences. 2018 Sep;39(9):812-827. DOI: 10.1016/j.tips.2018.07.003. Highlights Although circadian rhythm disruption (CRD) was typically considered to be a risk for chronic diseases solely for shift workers (∼20%...
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BACKGROUND INFORMATION Modern electric lighting enables people to work, sleep, eat, and receive services throughout the 24-hour day. As a result, many individuals encounter new patterns and types of electrical light, change the timing of their meals, and experience sleep disturbances and other stresses. Those factors can disrupt circadian rhythms and possibly lead to adverse...
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April 2021 Summary of NTP Cancer Hazard Conclusions Exposure Circumstances That Cause Circadian Disruption:Persistent Night Shift WorkCertain Lighting Conditions https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf Selected images: NTP Review of Shift Work at Night, Light at Night, and Circadian Disruption Topic Overview Status: NTP cancer hazard assessments Conclusion(s): NTP concluded that (1) persistent night shift work can cause breast cancer in women...
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Szkiela, M.; Kusideł, E.; Makowiec-Dąbrowska, T.; Kaleta, D. How the Intensity of Night Shift Work Affects Breast Cancer Risk. Int. J. Environ. Res. Public Health 2021, 18, 4570. https://doi.org/10.3390/ijerph18094570 Abstract Background—In 2019, the IARC concluded that “night shift work is probably carcinogenic to humans (Group 2A), based on limited evidence from human epidemiological studies and sufficient evidence of...
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Hatori M, Gronfier C, Van Gelder RN, et al. Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies. NPJ Aging and Mechanisms of Disease. 2017 ;3:9. DOI: 10.1038/s41514-017-0010-2. Abstract Mammals receive light information through the eyes, which perform two major functions: image forming vision to see objects and...
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Russart KLG, Nelson RJ. Light at night as an environmental endocrine disruptor. Physiol Behav. 2018 Jun 1;190:82-89. doi: 10.1016/j.physbeh.2017.08.029. Epub 2017 Sep 7. PMID: 28870443; PMCID: PMC5839924. https://www.sciencedirect.com/science/article/abs/pii/S0031938417302743?via%3Dihub Abstract Environmental endocrine disruptors (EEDs) are often consequences of human activity; however, the effects of EEDs are not limited to humans. A primary focus over the past...
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Zhang, Z., Zeng, P., Gao, W. et al. Circadian clock: a regulator of the immunity in cancer. Cell Commun Signal 19, 37 (2021). https://doi.org/10.1186/s12964-021-00721-2 Abstract The circadian clock is an endogenous timekeeper system that controls and optimizes biological processes, which are consistent with a master circadian clock and peripheral clocks and are controlled by various genes. Notably, the disruption of...
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Sommer AP. Mitochondrial solar sensitivity: evolutionary and biomedical implications. Ann Transl Med. 2020 Mar;8(5):161. doi: 10.21037/atm.2019.11.100. PMID: 32310246; PMCID: PMC7154450. Depending on cellular demand or oxidative stress, mitochondria produce adenosine triphosphate (ATP) or reactive oxygen species (ROS), thereby controlling the entire scale of cellular energy supply or disease, respectively. While deficiency in ROS can compromise...
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Hardell, Lennart and Carlberg, Michael. “Lost opportunities for cancer prevention: historical evidence on early warnings with emphasis on radiofrequency radiation” Reviews on Environmental Health, 2021. https://www.degruyter.com/document/doi/10.1515/reveh-2020-0168/html Note by EMFSA: the doi link above might not be active yet. Published Ahead of Print / Just Accepted Abstract Some historical aspects on late lessons from early warnings on...
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Bishehsari, F., Voigt, R.M. & Keshavarzian, A. Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer. Nat Rev Endocrinol 16, 731–739 (2020). https://doi.org/10.1038/s41574-020-00427-4 Abstract The metabolic syndrome is prevalent in developed nations and accounts for the largest burden of non-communicable diseases worldwide. The metabolic syndrome has direct effects on health and increases the risk of...
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