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Circadian Disruption
Curr Top Med Chem. 2019 Nov 17. doi: 10.2174/1568026619666191118110155. [Epub ahead of print] Abstract Abstract BACKGROUND: Sleep disorders have emerged as potential cancer risk factors. OBJECTIVE: This review discusses the relationships between sleep, obesity, and breathing disorders with concomitant risks of developing cancer. RESULTS: Sleep disorders result in an abnormal expression of clock genes, decreased immunity,...
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Horm Behav. 2019 Apr;110:77-89. doi: 10.1016/j.yhbeh.2019.02.018. Epub 2019 Mar 15. Abstract Circadian time-keeping mechanisms preserve homeostasis by synchronizing internal physiology with predictable variations in the environment and temporally organize the activation of physiological signaling mechanisms to promote survival and optimize the allocation of energetic resources. In this paper, we highlight the importance of the robust circadian...
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by Elise McGlashan, PhD & Parisa Vidafar, PhD on November 5, 2019 in Clocks in the Spotlight Image credit: Olivia Walch (Twitter: @OliviaWalch; website: www.oliviawalch.com)  Humans evolved in an environment with only very bright (sun) or very dim (moon or fire) sources of light. Today, artificial lighting enables us to spend hours per day at intermediate light levels. Our recent study shows...
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PNAS June 11, 2019 116 (24) 12019-12024; first published May 28, 2019 https://doi.org/10.1073/pnas.1901824116 Significance: Electric lighting has fundamentally altered how the human circadian clock synchronizes to the day/night cycle. Exposure to light after dusk is pervasive in the modern world. We examined group-level sensitivity of the circadian system to evening light and the degree to which sensitivity varies between individuals. We...
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Abstract Both obesity and breast cancer are already recognized worldwide as the most common syndromes in our modern society. Currently, there is accumulating evidence from epidemiological and experimental studies suggesting that these syndromes are closely associated with circadian disruption. It has been suggested that melatonin (MLT) and the circadian clock genes both play an important...
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Published: 17 October 2019  Abstract: Light is necessary for life, but prolonged exposure to artificial light is a matter of increasing health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by light-emitting diodes (LEDs), which can interfere with normal sleep cycles. The LED technologies are relatively new; therefore, the long-term...
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Mol Psychiatry. 2013 Jul;18(7):751-7. doi: 10.1038/mp.2013.70. Epub 2013 May 28. Abstract Humans and other organisms have adapted to a consistent and predictable 24-h solar cycle, but over the past ~130 years the widespread adoption of electric light has transformed our environment. Instead of aligning behavioral and physiological processes to the natural solar cycle, individuals respond to...
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Cancers 2019, 11(8), 1146; https://doi.org/10.3390/cancers11081146 Received: 10 July 2019 / Revised: 5 August 2019 / Accepted: 7 August 2019 / Published: 9 August 2019 (This article belongs to the Special Issue 3rd Etnean Occupational Medicine Workshop—Breast Cancer and Work) Abstract BRCA1 and BRCA2 genes are involved in DNA double-strand break repair and related to breast cancer. Shift work is associated with biological clock...
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5 July 2019 The results of the recent IARC Monographs evaluation of the carcinogenicity of night shift work have now been published in The Lancet Oncology. This summary article presents the conclusions of the IARC Monographs Meeting 124. Shift work involving circadian disruption was previously evaluated by the IARC Monographs, in 2007. In this updated evaluation, the Working Group chose the...
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Source: https://www.anses.fr/fr/content/led-les-recommandations-de-l%E2%80%99anses-pour-limiter-l%E2%80%99exposition-%C3%A0-la-lumi%C3%A8re-bleue While the use of LEDs is becoming more widespread for lighting and LED objects are on the increase, ANSES published the update of its 2010 expertise on the health effects of LEDs in light of the new scientific knowledge available. The Agency confirms the toxicity of blue light on the retina and highlights effects...
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