Tag

Circadian Disruption
Nassan, M., Videnovic, A. Circadian rhythms in neurodegenerative disorders. Nat Rev Neurol (2021). https://doi.org/10.1038/s41582-021-00577-7 In this Review, the authors discuss the alterations to the circadian system that occur in movement (Parkinson disease and Huntington disease) and cognitive (Alzheimer disease and frontotemporal dementia) neurodegenerative disorders and provide directions for future investigations in this field. https://www.nature.com/articles/s41582-021-00577-7
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Aiello I, Fedele MLM, Román F, Marpegan L, Caldart C, Chiesa JJ, Golombek DA, Finkielstein CV, Paladino N. Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation. Sci Adv. 2020 Oct 14;6(42):eaaz4530. doi: 10.1126/sciadv.aaz4530. PMID: 33055171; PMCID: PMC7556830. Abstract Circadian disruption negatively affects physiology, posing a global health threat that manifests in proliferative, metabolic,...
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Source: https://insite.ipwea.org/the-urgency-of-controlling-light-pollution/ Light pollution is defined as the inappropriate or excessive use of artificial light at night, and it is the fastest growing pollutant on the planet. Whilst astronomers lament the loss of stars, preventing over 80% of the world’s population from access to a natural sky, light pollution’s impacts are far more reaching. At...
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National Toxicology Program (NTP). 2021. NTP Cancer Hazard Assessment Report on Night Shift Work and Light at Night. Research Triangle Park, NC: National Toxicology Program. https://doi.org/10.22427/NTP-CHR-NSWLAN Report Date: April 2021 ABSTRACT Introduction Modern electric lighting practices have facilitated a society in which people may work, sleep, and receive goods and services at any time of the day. People...
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Ikegami, K., Refetoff, S., Van Cauter, E. et al. Interconnection between circadian clocks and thyroid function. Nat Rev Endocrinol 15, 590–600 (2019). https://doi.org/10.1038/s41574-019-0237-z Abstract Circadian rhythmicity is an approximately 24-h cell-autonomous period driven by transcription–translation feedback loops of specific genes, which are referred to as ‘circadian clock genes’. In mammals, the central circadian pacemaker, which is located in the hypothalamic...
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Citation: Blask DE, Dauchy RT, Dauchy EM, Mao L, Hill SM, Greene MW, et al. (2014) Light Exposure at Night Disrupts Host/Cancer Circadian Regulatory Dynamics: Impact on the Warburg Effect, Lipid Signaling and Tumor Growth Prevention. PLoS ONE 9(8): e102776. https://doi.org/10.1371/journal.pone.0102776 Abstract The central circadian clock within the suprachiasmatic nucleus (SCN) plays an important role in...
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Nankivell, V.A., Tan, J.T.M., Wilsdon, L.A. et al. Circadian disruption by short light exposure and a high energy diet impairs glucose tolerance and increases cardiac fibrosis in Psammomys obesus. Sci Rep 11, 9673 (2021). https://doi.org/10.1038/s41598-021-89191-7 Abstract Type 2 diabetes mellitus (T2DM) increases cardiac inflammation which promotes the development of cardiac fibrosis. We sought to determine the impact of circadian disruption on...
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BACKGROUND INFORMATION Modern electric lighting enables people to work, sleep, eat, and receive services throughout the 24-hour day. As a result, many individuals encounter new patterns and types of electrical light, change the timing of their meals, and experience sleep disturbances and other stresses. Those factors can disrupt circadian rhythms and possibly lead to adverse...
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April 2021 Summary of NTP Cancer Hazard Conclusions Exposure Circumstances That Cause Circadian Disruption:Persistent Night Shift WorkCertain Lighting Conditions https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf Selected images: NTP Review of Shift Work at Night, Light at Night, and Circadian Disruption Topic Overview Status: NTP cancer hazard assessments Conclusion(s): NTP concluded that (1) persistent night shift work can cause breast cancer in women...
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APRIL 21, 2021 by University of Waterloo https://medicalxpress.com/news/2021-04-shift-work-negative-impacts-health-affects.html Shift-work and irregular work schedules can cause several health-related issues and affect our defense against infection, according to new research from the University of Waterloo. These health-related issues occur because the body’s natural clock, called the circadian clock, can be disrupted by inconsistent changes in the sleep-wake schedule...
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