Tag

Circadian Disruption
Lee, Y. Roles of circadian clocks in cancer pathogenesis and treatment. Exp Mol Med 53, 1529–1538 (2021). https://doi.org/10.1038/s12276-021-00681-0 Abstract Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h rhythms in cellular and bodily functions across nearly all living species. These internal clock systems enable living organisms to anticipate and respond to daily changes in their environment in...
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Abele SH, Meadows KE, Medeiros D, Silver AC. Time is on the Immune System’s Side, Yes it is. Yale J Biol Med. 2019;92(2):225-231. Published 2019 Jun 27. Abstract From bacteria to mammals, nearly all organisms have adapted their physiology and behavior to a daily rhythm. These circadian (daily) rhythms influence virtually all aspects of physiological architecture...
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Citation: Clark GT, Yu Y, Urban CA, Fu G, Wang C, Zhang F, et al. (2022) Circadian control of heparan sulfate levels times phagocytosis of amyloid beta aggregates. PLoS Genet 18(2): e1009994. https://doi.org/10.1371/journal.pgen.1009994 http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009994 The findings provide a mechanism that links Alzheimer’s disease with circadian rhythm disruptions Peer-Reviewed Publication PLOS Researchers report that the immune cells...
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Citation: Lee Y, Lahens NF, Zhang S, Bedont J, Field JM, Sehgal A (2019) G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment. PLoS Biol 17(4): e3000228. https://doi.org/10.1371/journal.pbio.3000228 Abstract Circadian disruption has multiple pathological consequences, but the underlying mechanisms are largely unknown. To address such mechanisms,...
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Nassan, M., Videnovic, A. Circadian rhythms in neurodegenerative disorders. Nat Rev Neurol (2021). https://doi.org/10.1038/s41582-021-00577-7 In this Review, the authors discuss the alterations to the circadian system that occur in movement (Parkinson disease and Huntington disease) and cognitive (Alzheimer disease and frontotemporal dementia) neurodegenerative disorders and provide directions for future investigations in this field. https://www.nature.com/articles/s41582-021-00577-7
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Aiello I, Fedele MLM, Román F, Marpegan L, Caldart C, Chiesa JJ, Golombek DA, Finkielstein CV, Paladino N. Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation. Sci Adv. 2020 Oct 14;6(42):eaaz4530. doi: 10.1126/sciadv.aaz4530. PMID: 33055171; PMCID: PMC7556830. Abstract Circadian disruption negatively affects physiology, posing a global health threat that manifests in proliferative, metabolic,...
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Source: https://insite.ipwea.org/the-urgency-of-controlling-light-pollution/ Light pollution is defined as the inappropriate or excessive use of artificial light at night, and it is the fastest growing pollutant on the planet. Whilst astronomers lament the loss of stars, preventing over 80% of the world’s population from access to a natural sky, light pollution’s impacts are far more reaching. At...
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National Toxicology Program (NTP). 2021. NTP Cancer Hazard Assessment Report on Night Shift Work and Light at Night. Research Triangle Park, NC: National Toxicology Program. https://doi.org/10.22427/NTP-CHR-NSWLAN Report Date: April 2021 ABSTRACT Introduction Modern electric lighting practices have facilitated a society in which people may work, sleep, and receive goods and services at any time of the day. People...
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Ikegami, K., Refetoff, S., Van Cauter, E. et al. Interconnection between circadian clocks and thyroid function. Nat Rev Endocrinol 15, 590–600 (2019). https://doi.org/10.1038/s41574-019-0237-z Abstract Circadian rhythmicity is an approximately 24-h cell-autonomous period driven by transcription–translation feedback loops of specific genes, which are referred to as ‘circadian clock genes’. In mammals, the central circadian pacemaker, which is located in the hypothalamic...
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Citation: Blask DE, Dauchy RT, Dauchy EM, Mao L, Hill SM, Greene MW, et al. (2014) Light Exposure at Night Disrupts Host/Cancer Circadian Regulatory Dynamics: Impact on the Warburg Effect, Lipid Signaling and Tumor Growth Prevention. PLoS ONE 9(8): e102776. https://doi.org/10.1371/journal.pone.0102776 Abstract The central circadian clock within the suprachiasmatic nucleus (SCN) plays an important role in...
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