Tag

Circadian Disruption
31
Aug

Energy Saving LED Street Lights-The Unintended Consequences

August 31, 2022
Photo by Daniel Olah on Unsplash The intentions are good: help save the planet by reducing energy consumption from streetlights. Claims also include the reduction of light pollution. However, there could be unintended consequences associated with energy saving LED streetlights. Artificial Light at Night (ALAN), Light Pollution and Circadian Disruption: In many cases these new...
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26
Mar

Roles of circadian clocks in cancer pathogenesis and treatment

March 26, 2022
Lee, Y. Roles of circadian clocks in cancer pathogenesis and treatment. Exp Mol Med 53, 1529–1538 (2021). https://doi.org/10.1038/s12276-021-00681-0 Abstract Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h rhythms in cellular and bodily functions across nearly all living species. These internal clock systems enable living organisms to anticipate and respond to daily changes in their environment in...
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19
Mar

Time is on the Immune System’s Side, Yes it is

March 19, 2022
Abele SH, Meadows KE, Medeiros D, Silver AC. Time is on the Immune System’s Side, Yes it is. Yale J Biol Med. 2019;92(2):225-231. Published 2019 Jun 27. Abstract From bacteria to mammals, nearly all organisms have adapted their physiology and behavior to a daily rhythm. These circadian (daily) rhythms influence virtually all aspects of physiological architecture...
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17
Feb

Immune cells that clear away Alzheimer’s disease protein are controlled by circadian rhythms

February 17, 2022
Citation: Clark GT, Yu Y, Urban CA, Fu G, Wang C, Zhang F, et al. (2022) Circadian control of heparan sulfate levels times phagocytosis of amyloid beta aggregates. PLoS Genet 18(2): e1009994. https://doi.org/10.1371/journal.pgen.1009994 http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009994 The findings provide a mechanism that links Alzheimer’s disease with circadian rhythm disruptions Peer-Reviewed Publication PLOS Researchers report that the immune cells...
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07
Jan

G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment

January 7, 2022
Citation: Lee Y, Lahens NF, Zhang S, Bedont J, Field JM, Sehgal A (2019) G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment. PLoS Biol 17(4): e3000228. https://doi.org/10.1371/journal.pbio.3000228 Abstract Circadian disruption has multiple pathological consequences, but the underlying mechanisms are largely unknown. To address such mechanisms,...
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16
Nov

Circadian rhythms in neurodegenerative disorders

November 16, 2021
Nassan, M., Videnovic, A. Circadian rhythms in neurodegenerative disorders. Nat Rev Neurol (2021). https://doi.org/10.1038/s41582-021-00577-7 In this Review, the authors discuss the alterations to the circadian system that occur in movement (Parkinson disease and Huntington disease) and cognitive (Alzheimer disease and frontotemporal dementia) neurodegenerative disorders and provide directions for future investigations in this field. https://www.nature.com/articles/s41582-021-00577-7
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08
Oct

Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation

October 8, 2021
Aiello I, Fedele MLM, Román F, Marpegan L, Caldart C, Chiesa JJ, Golombek DA, Finkielstein CV, Paladino N. Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation. Sci Adv. 2020 Oct 14;6(42):eaaz4530. doi: 10.1126/sciadv.aaz4530. PMID: 33055171; PMCID: PMC7556830. Abstract Circadian disruption negatively affects physiology, posing a global health threat that manifests in proliferative, metabolic,...
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05
Jul

The Urgency of Controlling Light Pollution by Landon Bannister

July 5, 2021
Source: https://insite.ipwea.org/the-urgency-of-controlling-light-pollution/ Light pollution is defined as the inappropriate or excessive use of artificial light at night, and it is the fastest growing pollutant on the planet. Whilst astronomers lament the loss of stars, preventing over 80% of the world’s population from access to a natural sky, light pollution’s impacts are far more reaching. At...
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03
Jul

Abstract for Cancer Hazard Assessment: Night Shift Work and Light at Night

July 3, 2021,
National Toxicology Program (NTP). 2021. NTP Cancer Hazard Assessment Report on Night Shift Work and Light at Night. Research Triangle Park, NC: National Toxicology Program. https://doi.org/10.22427/NTP-CHR-NSWLAN Report Date: April 2021 ABSTRACT Introduction Modern electric lighting practices have facilitated a society in which people may work, sleep, and receive goods and services at any time of the day. People...
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13
Jun

Interconnection between circadian clocks and thyroid function

June 13, 2021
Ikegami, K., Refetoff, S., Van Cauter, E. et al. Interconnection between circadian clocks and thyroid function. Nat Rev Endocrinol 15, 590–600 (2019). https://doi.org/10.1038/s41574-019-0237-z Abstract Circadian rhythmicity is an approximately 24-h cell-autonomous period driven by transcription–translation feedback loops of specific genes, which are referred to as ‘circadian clock genes’. In mammals, the central circadian pacemaker, which is located in the hypothalamic...
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