• Oxidative stress based EMF exposure modulates nitric oxide level in the germ cells.
• Oxidative stress based EMF exposure inhibits antioxidant mechanisms in the germ cells.
EMF emitted by mobile phones has a number of well-documented adverse metabolomic effects on the male and female reproductive systems and can lead to infertility by increasing ROS production and reducing GSH and other antioxidants. The primary target of the EMF emitted by mobile phones may be the cell membrane (Pall in press, this volume). This then results in accelerated activity of membrane NADH oxidase and, consequently, greater rates of ROS formation that cannot be easily conjugated or detoxified. Although many studies have reported morphological and functional deteriorations in testis and ovary following EMF exposures, as well both structural and functional deficits in reproductive health, the underlying mechanisms have not been fully elucidated. To assist in further clarification of these processes and mechanisms, Table 1 summarizes key studies on the metabolomic effects of EMF on reproductive systems. Future studies will benefit greatly from standardized exposure protocols and evaluations of key metabolomic indicators.