NTP announces the peer review of the Draft Report on Carcinogens Monograph on Night Shift Work and Light at Night on Oct. 5, 2018 (Fed. Reg. 83(160): pages 41093-41095, Aug. 17, 2018).
Meeting begins at 8:30 a.m. EDT and continues until adjournment.
- The draft monograph will be available Aug. 24, 2018 on the Upcoming Peer Review Panels page.
- Sept. 21, 2018 is the deadline for written public comment submissions.
- Sept. 21, 2018 is the deadline for oral comment registration.
- Oct. 5, 2018 is the deadline for meeting registration and to view the webcast.
- Registration is required to view the webcast.
Federal Register notice, agenda, registration, and other meeting information are available on the Upcoming Peer Review Panels page.
Draft Report on Carcinogens Monograph on Night Shift Work and Light at Night; Availability of Document; Request for Comments; Notice of Peer-Review Meeting
Background: The invention of electric light transformed society, from one in which people’s activities and sleep patterns were limited by the natural light: Dark cycle to a culture in which people now work, sleep, eat, and receive goods or services throughout the 24-hour day. Through lifestyle choices, home location, and work schedule, people are exposed to different patterns and types of light, including electric light at night (LAN), which may lead to cancer and other adverse health effects. These health effects may arise from misalignment of daily physiological and behavioral cycles (i.e., circadian rhythms) with external stimuli or with each other (i.e., circadian disruption). Circadian rhythms can include processes and behaviors like sleep-wake cycles, eating, and body temperature, among others.
NTP has conducted a literature-based assessment and applied the Report on Carcinogens (RoC) listing criteria to this assessment to determine whether night shift work (e.g., working at least three hours between midnight and 6 a.m.) and light at night are cancer hazards. As circadian disruption is thought to be a key intermediate step, NTP has also reviewed the literature on this topic.
The monograph assesses the evidence from cancer studies in humans and experimental animals and mechanistic data and provides NTP’s preliminary recommendation regarding whether night shift work and or light at night should be listed in the Report on Carcinogens, and if so, how the two exposure scenarios should be defined. The listing categories include known or reasonably anticipated to be a human carcinogen. https://www.federalregister.gov/documents/2018/08/17/2018-17782/draft-report-on-carcinogens-monograph-on-night-shift-work-and-light-at-night-availability-of