Tag

Circadian Clock
Sulli G, Manoogian ENC, Taub PR, Panda S. Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases. Trends in Pharmacological Sciences. 2018 Sep;39(9):812-827. DOI: 10.1016/j.tips.2018.07.003. Highlights Although circadian rhythm disruption (CRD) was typically considered to be a risk for chronic diseases solely for shift workers (∼20%...
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Roy K, Maji D, Deb I. Increase of Cry 1 expression is a common phenomenon of the disturbed circadian clock in ischemic stroke and opioid addiction. Biochem Biophys Res Commun. 2021 Apr 21;558:8-13. doi: 10.1016/j.bbrc.2021.04.053. Epub ahead of print. PMID: 33894675. Abstract Increasing evidences suggest the involvement of disrupted circadian clock in various pathologies including...
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Chen HC, Chen YC, Wang TN, Fang WF, Chang YC, Chen YM, Chen IY, Lin MC, Yang MY. Disrupted Expression of Circadian Clock Genes in Patients with Bronchial Asthma. J Asthma Allergy. 2021 Apr 16;14:371-380. doi: 10.2147/JAA.S302508. PMID: 33888995; PMCID: PMC8057829. Abstract Purpose: Circadian clock is synchronized to the 24-hour day by the daily light-dark cycle...
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APRIL 21, 2021 by University of Waterloo https://medicalxpress.com/news/2021-04-shift-work-negative-impacts-health-affects.html Shift-work and irregular work schedules can cause several health-related issues and affect our defense against infection, according to new research from the University of Waterloo. These health-related issues occur because the body’s natural clock, called the circadian clock, can be disrupted by inconsistent changes in the sleep-wake schedule...
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Janjić, K., Agis, H. Chronodentistry: the role & potential of molecular clocks in oral medicine. BMC Oral Health 19, 32 (2019). https://doi.org/10.1186/s12903-019-0720-x Abstract Molecular clocks help organisms to adapt important physiological functions to periodically changing conditions in the environment. These include the adaption of the 24 h sleep-wake rhythm to changes of day and night. The circadian clock is...
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de Assis, L.V.M., Oster, H. The circadian clock and metabolic homeostasis: entangled networks. Cell. Mol. Life Sci. (2021). https://doi.org/10.1007/s00018-021-03800-2 Abstract The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of time for the organism. The synchrony between the daily challenges imposed by the environment needs to be aligned with biological processes...
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Haspel J, Kim M, Zee P, Schwarzmeier T, Montagnese S, Panda S, Albani A, Merrow M. A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care. J Biol Rhythms. 2021 Feb 11:748730421992587. doi: 10.1177/0748730421992587. Epub ahead of print. PMID: 33573430. Abstract We currently find ourselves in the midst of a global coronavirus disease...
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Ch, R., Rey, G., Ray, S. et al. Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells. Nat Commun 12, 377 (2021). https://doi.org/10.1038/s41467-020-20479-4 Abstract Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs),...
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Image credit BRIAN LANANNA Immune cells known as microglia (turquoise with red dots) surround a plaque of the Alzheimer’s protein amyloid (blue). The red dots indicate that the microglia are prepared to remove the potentially damaging plaque. Researchers at Washington University School of Medicine in St. Louis have discovered a protein that links the amyloid-removal...
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Xiong X, Lin Y, Lee J, Paul A, Yechoor V, Figuero M, Ma K. Chronic circadian shift leads to adipose tissue inflammation and fibrosis. Mol Cell Endocrinol. 2020 Dec 4:111110. doi: 10.1016/j.mce.2020.111110. Epub ahead of print. PMID: 33285245. Abstract The circadian clock exerts temporal coordination of metabolic pathways. Clock disruption is intimately linked with the...
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