Tag

Circadian Clock
Janjić, K., Agis, H. Chronodentistry: the role & potential of molecular clocks in oral medicine. BMC Oral Health 19, 32 (2019). https://doi.org/10.1186/s12903-019-0720-x Abstract Molecular clocks help organisms to adapt important physiological functions to periodically changing conditions in the environment. These include the adaption of the 24 h sleep-wake rhythm to changes of day and night. The circadian clock is...
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de Assis, L.V.M., Oster, H. The circadian clock and metabolic homeostasis: entangled networks. Cell. Mol. Life Sci. (2021). https://doi.org/10.1007/s00018-021-03800-2 Abstract The circadian clock exerts an important role in systemic homeostasis as it acts a keeper of time for the organism. The synchrony between the daily challenges imposed by the environment needs to be aligned with biological processes...
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Haspel J, Kim M, Zee P, Schwarzmeier T, Montagnese S, Panda S, Albani A, Merrow M. A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care. J Biol Rhythms. 2021 Feb 11:748730421992587. doi: 10.1177/0748730421992587. Epub ahead of print. PMID: 33573430. Abstract We currently find ourselves in the midst of a global coronavirus disease...
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Ch, R., Rey, G., Ray, S. et al. Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells. Nat Commun 12, 377 (2021). https://doi.org/10.1038/s41467-020-20479-4 Abstract Circadian clocks coordinate mammalian behavior and physiology enabling organisms to anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive these clocks in most of mammalian cells. However, red blood cells (RBCs),...
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Image credit BRIAN LANANNA Immune cells known as microglia (turquoise with red dots) surround a plaque of the Alzheimer’s protein amyloid (blue). The red dots indicate that the microglia are prepared to remove the potentially damaging plaque. Researchers at Washington University School of Medicine in St. Louis have discovered a protein that links the amyloid-removal...
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Xiong X, Lin Y, Lee J, Paul A, Yechoor V, Figuero M, Ma K. Chronic circadian shift leads to adipose tissue inflammation and fibrosis. Mol Cell Endocrinol. 2020 Dec 4:111110. doi: 10.1016/j.mce.2020.111110. Epub ahead of print. PMID: 33285245. Abstract The circadian clock exerts temporal coordination of metabolic pathways. Clock disruption is intimately linked with the...
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by Elise McGlashan, PhD & Parisa Vidafar, PhD on November 5, 2019 in Clocks in the Spotlight Image credit: Olivia Walch (Twitter: @OliviaWalch; website: www.oliviawalch.com)  Humans evolved in an environment with only very bright (sun) or very dim (moon or fire) sources of light. Today, artificial lighting enables us to spend hours per day at intermediate light levels. Our recent study shows...
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PNAS June 11, 2019 116 (24) 12019-12024; first published May 28, 2019 https://doi.org/10.1073/pnas.1901824116 Significance: Electric lighting has fundamentally altered how the human circadian clock synchronizes to the day/night cycle. Exposure to light after dusk is pervasive in the modern world. We examined group-level sensitivity of the circadian system to evening light and the degree to which sensitivity varies between individuals. We...
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Pflugers Arch. 2018 Feb;470(2):227-239. doi: 10.1007/s00424-017-2103-y. Epub 2018 Jan 4. Life on earth is shaped by the 24-h rotation of our planet around its axes. To adapt behavior and physiology to the concurring profound but highly predictable changes, endogenous circadian clocks have evolved that drive 24-h rhythms in invertebrate and vertebrate species. At the molecular level,...
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The Circadian Clock, Transcriptional Feedback and the Regulation of Gene Expression. The 2017 Nobel Lectures in Physiology or Medicine were held on 7 December at the Aula Medica, Karolinska Institutet.
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