Enjoy! https://mailchi.mp/emfsa/6-free-videos

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Link to the report: https://bit.ly/3HkQ4vh

Report chaired and presented by: James C Lech

Committee members 2022: page 43-44 of the report Timestamps:

0:00 Discussion continued from video 5

2:00 Don’t waste time trying to change people – grow them

4:00 Feeling hurt; horrible; low dopamine one cannot get better

7:00 Surfskate

11:33 Beach tennis

12:52 Brain with insufficient neurochemistry or ATP metabolism – impossible for growth and development

14:23 Person in Geneva Switzerland is not going to care about HIV/coupled haplotype/magnetic flux drop in South Africa

14:52 WHO: each country brings forward to learn and change

Thanks for watching

The post Video: South African National WHO EMF Report 2022 – Debriefing Webinar Part 6 appeared first on EMFSA.

Abstract

There is only one known portal system in the mammalian brain – that of the pituitary gland, first identified in 1933 by Popa and Fielding. Here we describe a second portal pathway in the mouse linking the capillary vessels of the brain’s clock suprachiasmatic nucleus (SCN) to those of the organum vasculosum of the lamina terminalis (OVLT), a circumventricular organ. The localized blood vessels of portal pathways enable small amounts of important secretions to reach their specialized targets in high concentrations without dilution in the general circulatory system. These brain clock portal vessels point to an entirely new route and targets for secreted SCN signals, and potentially restructures our understanding of brain communication pathways.

https://www.nature.com/articles/s41467-021-25793-z

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With the rapid development of electronic information in the past 30 years, technical achievements based on electromagnetism have been widely used in various fields pertaining to human production and life. Consequently, electromagnetic radiation (EMR) has become a substantial new pollution source in modern civilization. The biological effects of EMR have attracted considerable attention worldwide. The possible interaction of EMR with human organs, especially the brain, is currently where the most attention is focused. Many studies have shown that the nervous system is an important target organ system sensitive to EMR. In recent years, an increasing number of studies have focused on the neurobiological effects of EMR, including the metabolism and transport of neurotransmitters. As messengers of synaptic transmission, neurotransmitters play critical roles in cognitive and emotional behavior. Here, the effects of EMR on the metabolism and receptors of neurotransmitters in the brain are summarized.

Extract only, for the full study see https://www.frontiersin.org/articles/10.3389/fpubh.2021.691880/full

Conclusion

In summary, research on the synthesis, metabolism and transport of neurotransmitters in the brain by EMR is increasing gradually, but due to the different parameters of EMR, experimental objects and conditions, the experimental results are not very consistent and comparative. Therefore, the effects of EMR on the metabolism and transport of neurotransmitters have not been clarified. Moreover, the role of neurotransmitters and their mechanism in the neurobehavioral dysfunction induced by EMR have not been revealed. Further detailed studies are needed. On the other hand, because of the complex diversity of neurotransmitters in the brain, the interaction, cotransmission and coregulation of neurotransmitters make it difficult to distinguish the primary and secondary changes of each neurotransmitter. Furthermore, the interaction of different neural nuclei in the brain constitutes sophisticated neural circuits, which is the fundamental basis of how the brain performs functions. Consequently, the regulation of neural circuits may be involved in the neurotransmitter disorder of the brain induced by EMR.

https://www.frontiersin.org/articles/10.3389/fpubh.2021.691880/full

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Abstract

Daily rhythms of behavior and neurophysiology are integral to the circadian clocks of all animals. Examples of circadian clock regulation in the human brain include daily rhythms in sleep-wake, cognitive function, olfactory sensitivity, and risk for ischemic stroke, all of which overlap with symptoms displayed by many COVID-19 patients. Motivated by the relatively unexplored, yet pervasive, overlap between circadian functions and COVID-19 neurological symptoms, this perspective piece uses daily variations in the sense of smell and the timing of sleep and wakefulness as illustrative examples. We propose that time-stamping clinical data and testing may expand and refine diagnosis and treatment of COVID-19.

https://journals.sagepub.com/doi/10.1177/07487304211031206

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Participate in research

Are you between 11 and 99 years old?

The Centre for Chronobiology in Basel (Switzerland) is looking for young people aged 11 years or older to complete a online survey on sleep and light exposure. It will take about 15-20 minutes, and there are no restrictions on country of residence.

Click HERE to participate!

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Citation: Weinzaepflen, C. & Spitschan, M. (Ed.) (2021). Enlighten your clock: How your body tells time. (C. Weinzaepflen, Illus.). DOI: 10.17605/OSF.IO/ZQXVH

Free download available from https://enlightenyourclock.org/

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Abstract

Many aspects of chemistry and biology are mediated by electromagnetic field (EMF) interactions. The central nervous system (CNS) is particularly sensitive to EMF stimuli. Studies have explored the direct effect of different EMFs on the electrical properties of neurons in the last two decades, particularly focusing on the role of voltage-gated ion channels (VGCs). This work aims to systematically review published evidence in the last two decades detailing the effects of EMFs on neuronal ion channels as per the PRISM guidelines. Following a predetermined exclusion and inclusion criteria, 22 papers were included after searches on three online databases. Changes in calcium homeostasis, attributable to the voltage-gated calcium channels, were found to be the most commonly reported result of EMF exposure. EMF effects on the neuronal landscape appear to be diverse and greatly dependent on parameters, such as the field’s frequency, exposure time, and intrinsic properties of the irradiated tissue, such as the expression of VGCs. Here, we systematically clarify how neuronal ion channels are particularly affected and differentially modulated by EMFs at multiple levels, such as gating dynamics, ion conductance, concentration in the membrane, and gene and protein expression. Ion channels represent a major transducer for EMF-related effects on the CNS.

https://pubmed.ncbi.nlm.nih.gov/33945157/

Extract

Limitations of this study

This study investigates a complex field, with sometimes conflicting results. The many variables that influence the impact of EMF exposure on neural tissue, such as the physiological state of the cell, its developmental stage, and the various physical characteristics of the many fields involved, complicate the reproducibility and often impede a consistent comparison between different studies. In spite of having highlighted some recurring patterns in the reported results, this review is, therefore, limited by the intrinsic differences of the studies reviewed.

Conclusion

Extract

Improved experimental reproducibility will be key to any advances in this field, and the development of new experimental procedures capable of measuring the small but profound way in which certain types of EMF exposure seem to affect our brain might help us to establish whether it is harmful and its therapeutic potential. We hope this work will help in improving our knowledge about the molecular dynamics of neuronal VGCs, which will be key both for any progress in the treatment of neurodegenerative diseases and for an advancement in the general understanding of the relationship between technological progress and cellular dynamics.

https://nyaspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/nyas.14597

© 2021 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals LLC on behalf of New York Academy of Sciences.

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Abstract

Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily rhythms in sinoatrial (SA) and atrioventricular (AV) node activity, and impose a time-of–day dependent susceptibility to ventricular arrhythmia. Critically, the balance of circadian inputs from the autonomic nervous system and cardiomyocyte clock to the SA and AV nodes differ, and this renders the cardiac conduction system sensitive to decoupling during abrupt shifts in behavioural routine and sleep-wake timing. Our findings reveal a functional segregation of circadian control across the heart’s conduction system and inherent susceptibility to arrhythmia.

Extract

It is clear that long-term shift work is associated with an elevated risk of cardiovascular disease, the incidence of cardiac events, and altered electrophysiological parameters^{15,45,46,47,48}. Whether alteration of cardiac conduction parameters during mistimed sleep and shift-work routines increases susceptibility to arrhythmia or other harmful cardiac events in otherwise healthy humans is not yet clear. Nevertheless, it is likely to be of important clinical consideration in patients with pre-existing cardiac dysfunction or injury, as well as in relation to ECG-based diagnoses and pharmacological intervention, where the time of day, patient occupation, and/or sleep–wake history may significantly impact the outcome. Moreover, we show that susceptibility to VT was rarely observed upon cardiomyocyte Bmal1 deletion, indicating that the circadian clock drives increased excitability during the active period of the day at the cost of creating vulnerability to arrhythmias. This suggests that clock function within the heart contributes to the long-known temporal variation in cardiac arrhythmia propensity observed in humans. Given the widespread influence of the circadian clock and established detrimental consequences of clock disruption, any clock-directed intervention must be approached with caution. Nevertheless, our findings offer an important and logical new avenue for therapeutic investigation.

https://www.nature.com/articles/s41467-021-22788-8

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Abstract

Natural sunlight permits organisms to synchronize their physiology to the external world. However, in current times, natural sunlight has been replaced by artificial light in both day and nighttime. While in the daytime, indoor artificial light is of lower intensity than natural sunlight, leading to a weak entrainment signal for our internal biological clock, at night the exposure to artificial light perturbs the body clock and sleep. Although electric light at night allows us “to live in darkness”, our current lifestyle facilitates nighttime exposure to light by the use, or abuse, of electronic devices (e.g., smartphones). The chronic exposure to light at nighttime has been correlated to mood alterations, metabolic dysfunctions, and poor cognition. To decipher the brain mechanisms underlying these alterations, fundamental research has been conducted using animal models, principally of nocturnal nature (e.g., mice). Nevertheless, because of the diurnal nature of human physiology, it is also important to find and propose diurnal animal models for the study of the light effects in circadian biology. The present review provides an overview of the effects of light at nighttime on physiology and behavior in diurnal mammals, including humans. Knowing how the brain reacts to artificial light exposure, using diurnal rodent models, is fundamental for the development of new strategies in human health based in circadian biology.

https://www.mdpi.com/2624-5175/3/2/14/htm

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