Abstract

Circadian disruption negatively affects physiology, posing a global health threat that manifests in proliferative, metabolic, and immune diseases, among others. Because outputs of the circadian clock regulate daily fluctuations in the immune response, we determined whether circadian disruption results in tumor-associated immune cell remodeling, facilitating tumor growth. Our findings show that tumor growth rate increased and latency decreased under circadian disruption conditions compared to normal light-dark (LD) schedules in a murine melanoma model. Circadian disruption induced the loss or inversion of daily patterns of M1 (proinflammatory) and M2 (anti-inflammatory) macrophages and cytokine levels in spleen and tumor tissues. Circadian disruption also induced (i) deregulation of rhythmic expression of clock genes and (ii) of cyclin genes in the liver, (iii) increased CcnA2 levels in the tumor, and (iv) dampened expression of the cell cycle inhibitor p21^WAF/CIP1 , all of which contribute to a proliferative phenotype.

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

https://www.science.org/doi/10.1126/sciadv.aaz4530

The post Circadian disruption promotes tumor-immune microenvironment remodeling favoring tumor cell proliferation appeared first on EMFSA.

Abstract:

Purpose: The present study aimed to investigate the effect of extremely low frequency electromagnetic fields (ELF-EMFs) on proinflammatory cytokines and hematological parameters, among the employees of a power plant, which are one of the most important occupational groups exposed to ELF-EMFs extensively.

Materials and methods: The studied population included 112 employees of a power plant as the exposed group and 138 unexposed employees who were enrolled based on inclusion and exclusion criteria. The magnetic flux density and the strength of the electric field were determined by spot measurements and according to the IEEE C95.3.1 standard. Proinflammatory cytokines including serum interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumour necrosis factor-α (TNF-α); and hematologic parameters of all subjects were measured.

Results: The mean level of IL-1β and IL-6, white blood cell count (WBC) and red blood cell count (RBC), lymphocyte percentage (Lym%), Mean corpuscular volume (MCV), platelet count (PLT) and procalcitonin (PCT) were significantly more in the exposed group, than the unexposed group. The mean serum levels of IL-6, IL-1β and some of the hematological parameters including WBC, lymphocyte, RBC and haematocrit were higher in technicians which had the highest level of exposure to magnetic fields compared to other groups and these relations were linear.

Conclusions: Long-term exposure to ELF-EMFs probably affects immune responses, by stimulating the production of proinflammatory cytokines, and increasing some hematological parameters.

The post Effect of Long-term Occupational Exposure to Extremely Low Frequency Electromagnetic Fields on Proinflammatory Cytokine and Hematological Parameters appeared first on EMFSA.

The post Exposure to radiation from single or combined radio frequencies provokes macrophage dysfunction in the RAW 264.7 cell line appeared first on EMFSA.

The post The potential risks to human health from 5G: Reykjavik, Iceland: International Conference appeared first on EMFSA.