Lai, YF., Wang, HY. & Peng, RY. Establishment of injury models in studies of biological effects induced by microwave radiation. Military Med Res 8, 12 (2021). https://doi.org/10.1186/s40779-021-00303-w
Microwave radiation has been widely used in various fields, such as communication, industry, medical treatment, and military applications. Microwave radiation may cause injuries to both the structures and functions of various organs, such as the brain, heart, reproductive organs, and endocrine organs, which endanger human health. Therefore, it is both theoretically and clinically important to conduct studies on the biological effects induced by microwave radiation. The successful establishment of injury models is of great importance to the reliability and reproducibility of these studies. In this article, we review the microwave exposure conditions, subjects used to establish injury models, the methods used for the assessment of the injuries, and the indicators implemented to evaluate the success of injury model establishment in studies on biological effects induced by microwave radiation.
The World Health Organization (WHO) has listed electromagnetic radiation as one of the most common and fastest growing environmental influences . Microwave radiation is a form of electromagnetic waves, with frequencies ranging from 300 MHz to 300 GHz. Microwave radiation has been widely used in various fields, such as communication, industry, medical treatment, and the military. Previous studies have shown that microwave radiation can cause injuries to both the structures and functions of the brain, heart, reproductive organs and endocrine organs, which endangers human health [2,3,4,5,6,7,8,9]. Studies on the biological effects induced by microwave radiation are essential for unveiling the mechanisms of these injuries and promoting the development of more efficient prevention methods and more profound treatment strategies. Successful establishment of injury models plays an important role in studies on the biological effects of microwave radiation. Not only is the successful establishment of injury models the premise of these studies, but it also has great importance to their reliability and reproducibility.
Generally, the establishment of injury models induced by microwave radiation requires stable microwave exposure conditions, suitable subjects, appropriate methods, and reliable biological indicators. The stable microwave exposure conditions promise the reproducibility of the microwave-radiation-induced biological effects . Suitable subjects sensitive to specific microwave radiation injuries are essential in establishing different types of injury models. The appropriate methods are helpful in screening biological indicators sensitive to microwave radiation, which are important for assessing the successful establishment of injury models, understanding the underlying mechanisms of microwave radiation injuries, and laying foundations for corresponding clinical diagnosis and the development of targeted therapeutic drugs.