Volume 432, 15 April 2020, Pages 216-228
Fasciani I, Petragnano F, Aloisi G, Marampon F, Rossi M, Coppolino MF, Rossi R, Longoni B, Scarselli M, Maggio R. A New Threat to Dopamine Neurons: The Downside of Artificial Light. Neuroscience. 2020 Apr 15;432:216-228. doi: 10.1016/j.neuroscience.2020.02.047. Epub 2020 Mar 4. PMID: 32142863.
• Artificial light could indirectly damage dopamine neurons blunting the circadian rhythms of melatonin secretion.
• Artificial light could directly damage dopamine neuron by photoactivating biological relevant molecules.
• Light can modify the firing rate of dopamine neurons by activating opsins expressed in the substantia nigra.
• Excessive artificial light could be an adjunctive environmental risk factor for Parkinson’s disease.