Dental Amalgam Fillings and the Use of Technological Devices as an Environmental Factor: Updating the Cumulative Mercury Exposure-based Hypothesis of Autism

Abstract:

The molecular basis of autism spectrum disorders (ASD) still remains obscure and little is known about the specific gene-environment interactions that may increase the prevalence of the disorder. There has been a lot of controversy in the past regarding the association of thimerosal, a mercury (Hg)-containing preservative in vaccines, and the increased probability of developing autism among children. In 2011, as a more consensual theory, we alternatively proposed the “cumulative Hg exposure-based hypothesis” which considers not only one but the total contribution of different environmental sources of this element, such as maternal amalgam fillings, pollution, food, and also thimerosal-preserved vaccines together with a genetic/biochemical susceptibility to remove Hg from the body. Recently, researchers have shown that exposure to microwave radiation emitted by common technological devices (e.g., mobile phones, mobile base stations, and MRI machines) can lead to increased release of Hg from dental amalgam fillings. Therefore, we postulate that all these recent findings, far from being conflictive, are consistent with our previous hypothesis and could be included as an additional environmental factor contributing to the release of Hg in mothers with dental amalgam fillings and consequently, to the increased probability of developing and/or aggravating autism among children.

Dental Amalgam Fillings and the Use of Technological Devices as an Environmental Factor: Updating the Cumulative Mercury Exposure-based Hypothesis of Autism (PDF Download Available). Available from: https://www.researchgate.net/publication/319174009_Dental_Amalgam_Fillings_and_the_Use_of_Technological_Devices_as_an_Environmental_Factor_Updating_the_Cumulative_Mercury_Exposure-based_Hypothesis_of_Autism [accessed Dec 01 2017].
REFERENCES
1.Zeidán-Chuliá F, Rybarczyk-Filho JL, Salmina AB, de Oliveira BH,
Noda M, Moreira JC. Exploring the multifactorial nature of autism
through computational systems biology: Calcium and the Rho GTPase
RAC1 under the spotlight. Neuromolecular Med 2013;15:364-83.

2. Zeidán-Chuliá F, Salmina AB, Noda M, Verkhratsky A. Rho GTPase

RAC1 at the molecular interface between genetic and environmental
factors of autism spectrum disorders. Neuromolecular Med
2015;17:333-4.
3. Zeidán-Chuliá F, Gursoy UK, Könönen E, Gottfried C dental look
at the autistic patient through orofacial pain. Acta Odontol Scand
2011;69:193-200.
4. Sage C, Burgio E. Electromagnetic fields, pulsed radiofrequency
radiation, and epigenetics: How wireless technologies may affect
childhood development. Child Dev 2017. doi: 10.1111/cdev.12824.
5. Alsaeed I, Al-Somali F, Sakhnini L, Aljarallah OS, Hamdan RM,
Bubishate SA, et al. Autism-relevant social abnormalities in mice
exposed perinatally to extremely low frequency electromagnetic fields.
Int J Dev Neurosci 2014;37:58-64.
6. Mortazavi SM, Neghab M, Anoosheh SM, Bahaeddini N, Mortazavi G,
Neghab P, et al. High-field MRI and mercury release from dental
amalgam fillings. Int J Occup Environ Med 2014;5:101-5.
7. Mortazavi G, Haghani M, Rastegarian N, Zarei S, Mortazavi SM.
Increased release of mercury from dental amalgam fillings due to
maternal exposure to electromagnetic felds as a possible mechanism
for the high rates of autism in the offspring: Introducing a hypothesis.
J Biomed Phys Eng 2016;6:41-6.

Dental Amalgam Fillings and the Use of Technological Devices as an Environmental Factor: Updating the Cumulative Mercury Exposure-based Hypothesis of Autism (PDF Download Available). Available from: https://www.researchgate.net/publication/319174009_Dental_Amalgam_Fillings_and_the_Use_of_Technological_Devices_as_an_Environmental_Factor_Updating_the_Cumulative_Mercury_Exposure-based_Hypothesis_of_Autism [accessed Dec 01 2017].

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Our readers might find the following studies interesting:
Increased mercury release from dental amalgam restorations after exposure to electromagnetic fields as a potential hazard for hypersensitive people and pregnant women. https://www.ncbi.nlm.nih.gov/pubmed/26544100
Effect of radiofrequency radiation from Wi-Fi devices on mercury release from amalgam restorations. https://jehse.biomedcentral.com/articles/10.1186/s40201-016-0253-z
Effect of mobile phone use on metal ion release from fixed orthodontic appliances. https://www.ncbi.nlm.nih.gov/pubmed/26038076

 

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